One side effect often makes supplementing niacin a less than pleasurable experience, limiting adherence. Some patients experience flushing when supplementing niacin. However, a properly manufactured, sustained-release niacin circumvents this side effect. By using a proprietary, natural wax-matrix coating technology, Time Release Niacin is released slowly over a six- to eight-hour period to reduce flushing. Suggested Use: 1 tablet three times per day with a meal or as recommended by your health care professional.