Diindolylmethane (DIM) is one molecule known for the supportive role it plays in stimulating natural detoxification enzymes and supporting normal estrogen metabolism. As a natural component derived from indole – 3 – carbinole and cruciferous vegetables, DIM has shown in studies to support the 2 – hydroxylation instead of 16 – hydroxylation of certain estrogen metabolites. Research shows premenstrual symptoms are associated with high estrogen and low progesterone levels in the luteal phase. DIM works in conjunction with chaste berry extract to balance estrogen ratios. BioResponse DIM® is the only diindolymethane with proven absorption and activity demonstrated in independently performed clinical studies. BioResponse DIM® contains pure DIM, microencapsulated in particles complexed with a vitamin E derivative and phospholipids to aid absorption from our intestinal tract. ‡
Chaste berry extract, or Vitex agnus – castus , is a plant extract with active constituents from the fruit of the Chaste tree . Premenstrual symptoms (PMS) may be due to high physiologic prolactin levels due to stress or deep sleep phases. A randomized controlled trial show ed that Vitex agnus – castus supports the release of prolactin.
Vitamin D3 is a fat – soluble vitamin that plays a role in numerous health functions , as well as aids in intestinal magnesium absorption. Vitamin D support s cyclic fluctuations during the menstrual cycle that may help explain some features of PMS. Magnesium levels have been noted to fluctuate across the menstrual cycle and are involved in many cellular pathways and neuromuscular activities which effect PMS. Magnesium ma y support cramping and bloating. Several clinical trials showed that B vitamins, especially vitamin B – 6, support symptoms of PM S, especially mood and behavioral symptoms. Folate, supplied as the bioavailable methylfolate in PMS Support, is recommended while taking oral contraceptives due to folate interactions .
Iron supplementation is helpful in menstruating women to support the maintenance of healthy iron stores. Ferronyl® is a carbonyl form of iron that is bioavailable and well tolerated.