Research indicates that specific nutraceuticals help to support joint, tendon, ligament, and soft tissue health. Nutrients such as Boswellia serrata, MSM, and a new ingredient solubilized keratin have been clinically shown to support healthy joints.ƒ A specific Boswellia serrata extract called AprésFlex® provides a standardized bioavailable amount of Acetyl-11-keto-b-boswellic acid (AKBA), clinically shown to target mediators of joint comfort and flexibility, such as TNF-alpha and 5-lipoxygenase (5-LOX). 5-LOX is a member of the lipoxy-genase family of enzymes and excess levels of this enzyme sets in motion undesirable responses that have been linked to common joint conditions in aging individuals. Other Boswellia serrata extracts can be poorly absorbed, however AprèsFlexŽ has been shown to absorb into the blood 52% more than other boswellia extracts. AprésFlex® has been shown to inhibit MMP-3 (matrix metalloproteinase-3) enzyme activity, therefore supporting the integrity of cartilage and connective tissues.ƒ Cynatine® FLX is a natural bioactive keratin extracted from premium quality pure New Zealand wool using a unique patented process.
Keratin is a protein found throughout the body and has an important structural cells and tissue. This intriguing protein also has one of the highest proportions of the amino acid cysteine, a natural reservoir of sulphur and an antioxidant used in many biological reactions. Much of the structural strength of keratin comes from the amino acid cysteine, which can bridge to form a cystine bond. The ability to convert natural keratin into a functional form that is bio-available to the body is a recent breakthrough. A patented process now enables the intact keratin molecule to be solubilized, therefore making it both bioactive and bio-available to the body. Human clinical trials using 500 mg of Cynatine® FLX showed positive results in subjective WOMAC pain, stiffness, and activity scores.ƒ MSM, a derivative of DMSO, is a naturally occurring compound of biologically available sulfur. Sulfur is also an essential element for the glycosaminoglycans of connective tissues and cartilage, and serves as a versatile donor of metabolically active sulfur for the synthesis of numerous organosulfur compounds and proteins in the body. Antioxidants such as pine bark extract, spinach and strawberry, provide polyphenols that assist in normal regulatory processes.ƒ Manganese and amino acids, in particular L-Arginine, Glycine, and L-Proline, are important for collagen, cartilage and tissue synthesis. L-Arginine is a precursor to L-proline which can in turn increase cellular replication. As joints age, hyaluronic acid, the fluid that provides lubrication between joints and connective tissue, begins to break down. Hyaluronic acid (HA) is a large polysaccharide found in connective tissue. HA forms large, bulky molecular chains that allow joints to move smoothly and provides a cushion between the joints.