Approximately 10Œ20% of the world™s population is affected by a digestive disorder, but almost everybody experiences gastrointestinal discomfort at some point. There are several reasons for the development of intestinal discomfort, including daily stress, food sensitivities or intolerances, genetic predisposition, altered gut flora or the deregulation of brain-gut communication. Physiologically, the discomfort occurs as a result of contractions of the ileum, which lead to altered intestinal mobility and symptoms such as cramps, bloating and spasms. Fortunately, there are new supplemental ingredients that can support these symptoms through specific modes of action. Benegut is a water extraction of Perilla frutescens (L.) leaves, an annual edible herbaceous plant native to Asia with the common name Shiso. Benegut is standardized to a special flavonoid fraction, with its key active ingredient Vicenin 2 and rosmarinic acid. Both Benegut and isolated Vicenin 2 demonstrated in clinical research to have inhibiting musculotropic and neurotropic activity, as well as cholinergic activity, which results in a balanced bowel function and increased regularity. The brain-gut axis plays a role in gastrointestinal dysfunction by psychological factors such as stress influencing the enteric nervous system of the intestine. Benegut may interact with the neurological system and therefore counteract the effects of psychosocial factors.