Hawthorn’s berries and flowering tops have been used medicinally for close to two millennia as a treatment for digestive problems, kidney and bladder stones, and as a diuretic. Only recently has hawthorn’s cardioprotective benefits been recognized. Today hawthorn is perceived, especially in Europe, as a prime supplement for healthy cardiovascular support. The cardiotherapeutic properties of hawthorn are due to its high content of many biologically active flavonoid compounds, including anthocyanidins, proanthocyanidins, quercetin, vitexin, vitexin ramnoside, as well as catechin and epicatechin. Hawthorn extract has been shown in human as well as animal studies to improve circulation by dilating coronary blood vessels. Dilation of these blood vessels consequently increases blood, and thus oxygen supply to the heart. Components of hawthorn extract have also been demonstrated to inhibit angiotensin-converting enzyme, thus reducing blood vessel constriction. Hawthorn extract normalizes heart rate, as well as providing a positive inotropic effect. These properties of hawthorn, together with its vasodilatory and diuretic effects, are the basis for its use in cardiovascular support.