Flavonoids carry out important metabolic and an tioxidant functions in the body, scavenging many potentially damaging free radicals. Many flavonoids are also capable of binding to metal ions, which prevents these metals from acting as catalysts that enhance free radical production in the body. In addition, flavonoids support the health of the body’s circulatory system by helping maintain proper vascular permeability, integrity, and resiliency. Flavonoids also have a wide array of other biochemical functions. For example, flavonoids are involved in immune function, gene expression, capillary and cerebral blood flow, platelet aggregation, liver function, and collagen, phospholipid, and cholesterol metabolism.
Pycnogenol ® and Grape Seed Extract : Pine bark extract (Pycnogenol®) and grape seed extract are rich in proanthocyanidins, are highly regarded for their antioxidant properties and their role in supporting the body’s connective tissues a s well as capillaries . † FlavonAll ® provides the original pine bark extract from the European coastal pine containing a minimum of 65 % proanthocyanidins. A high – quality European grape seed extract (from Vitis vinifera ) with a minimum of 90% proanthocyanidins is also included.
Red Grape Skin Extract : The skins of red and black grapes are rich in the dark red – violet flavonoids, the polyphenols that are also present in red wine. Studies show red grape skin may inhibit glycation through its beneficial antioxidant properties. † Advanced glycation end products (AGEs) are proteins or lipids that become glycated after exposure to sugars. The presence and accumulation of AGEs in many different cell types affect extracellular and intracellular structure and function. In high blood sugar environments and in natural aging, AGEs alter cell structure and normal vascular function. Crucial to maintaining healthy AGE formation is optimal antioxidant support . Grape seed extract may also have a beneficial effect on blood pressure.
Bilberry Extract : Bilberries ( Vaccinium myrtillus ), a northern European cousin of the North American blueberries, are a rich source of anthocyanosides. Aside from its antioxidant activity , bilberry anthocyanosides were found to be important for eye health, capillary stability and blood flow.
Green Tea Extract : Green tea ( Camellia sinensis ) is one of the most widely consumed beverages in the world. Scientists have identified numerous phytochemicals including polyphenols, methylxanthines, flavonoids, and triterp enoid saponins in green tea. The polyphenols contained in tea, often referred to as catechins, appear to provide the primary health promoting benefits associated with green tea consumption. Catechin, epi – catechin, epi – gallocatechin (EGC), and most notably EGC gallate act as antioxidants to support immune function and cardiovascular health.
Ginkgo Biloba Extract : Known in traditional Chinese folklore for about 5,000 years, the leaves of the Ginkgo biloba tree provide flavonoids as flavone glycosides and terpene lactones, which are non – flavonoid phytochemicals. Numerous studies have evaluated the influence of ginkgo terpene lactones on capillary and cerebral microcirculation. † Ginkgo biloba extract is also reported to inhibit the tendency of red blood cells to stick together (“clumping”), thereby enhancing the fluidity of the blood. † Gingko biloba extract is respected for its potency and purity, and is derived only from young, fresh leaves that are especially rich in flavone glycosides and terpene lactones.
Milk Thistle Extract : Milk thistle ( Silybum marianum ) , a common herb native to the Mediterranean, has be en widely used for its nutritional support of liver function for over 2,000 years. Seeds of the dried milk thistle flower are rich in silymarin, a bioflavonoid complex of three flavonolignins: silybin, silydianin, and silychristin. Silymarin is responsible for milk thistle’s supportive and detoxification activities in the liver.
Citrus Bioflavonoids : The pith of citrus peels is especially rich in the bitter tasting flavanones hesperidin and naringin . Citrus juices, however, are low in bioflavonoids. Like most flavonoids, those from citrus work in synergy with vitamin C, bind to metal ions, preventing these metals from catalyzing enhanced free radical production. †Many bioflavonoids support the health of the body’s circulatory system by helping maintain healthy capillary blood flow and proper vascular permeability and integrity.