Coenzyme Q10 is an important rate-limiting nutrient that is a cofactor in the mitochondrial electron transport chain, the biochemical pathway in cellular respiration from which adenosine triphosphate (ATP) and metabolic energy is derived. Since nearly all cellular activities are dependent upon energy, coenzyme Q10 is essential for the health of all human tissues and organs, especially the heart. Given the strength of the science that has been emerging for the use of supplemental CoQ10, it is important to ensure that optimal CoQ10 levels are achieved in the blood following supplementation. Biochemically, it functions much like vitamin E in that it participates in certain antioxidant and free radical reactions. Numerous studies indicate coenzyme Q10 also plays an important role in the maintenance of the entire cardiovascular system. Coenzyme Q10 is also important for the maintenance of blood vessels and heart muscle function. In addition, statin drugs have been shown to impact coenzyme Q10 levels, therefore, individuals taking statin drugs may benefit from additional CoQ10 supplementation. And, as recent data indicate, it supports mitochondrial membrane proteins and protects DNA from oxidative stress. Coenzyme Q-10 is a large lipophilic nutrient that is best absorbed when a source of dietary fat is present such as lecithin. As a lipid-soluble nutrient with antioxidant properties, coenzyme Q10 efficiently supports membrane phospholipids and serum low-density lipoproteins from lipid peroxidation. And, as recent data indicate, it supports mitochondrial membrane proteins and DNA from free radical induced oxidative damage. Coenzyme Q10 has also been shown to extend the life of the potent antioxidant, vitamin E. Healthy people have the ability to synthesize adequate amounts of coenzyme Q10. According to Dr. Karl Folkers and other researchers, humans can synthesize coenzyme Q10 from the amino acids tyrosine or phenylalanine and mevalonic acid, all of which are abundant in the body. However, the synthesis is a complex process involving 15 separate steps which require many enzymes, nutritional mineral cofactors, and vitamin coenzymes. As a result, the biosynthesis of coenzyme Q10 in the human body requires a good diet Œ one that is high in vitamins, minerals, and other nutrient factors. Yet, it has been shown by NHANES I and II studies that many Americans do not consume an adequate diet. Rather, for many, dietary intake of water soluble vitamins, vitamin A, and some minerals and trace elements is insufficient. Many of these nutrients are essential for the biosynthesis of coenzyme Q10. Thus, it is not surprising that the nutritional status of coenzyme Q10 tends to decline during the normal aging process. Coenzyme Q10 has been established as an essential nutrient for the health of every cell in the human body.